ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising...

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Detalles Bibliográficos
Autores principales: Wells, Daniel, Bitoun, Emmanuelle, Moralli, Daniela, Zhang, Gang, Hinch, Anjali, Jankowska, Julia, Donnelly, Peter, Green, Catherine, Myers, Simon R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494361/
https://www.ncbi.nlm.nih.gov/pubmed/32744506
http://dx.doi.org/10.7554/eLife.53392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494361/
https://www.ncbi.nlm.nih.gov/pubmed/32744506
http://dx.doi.org/10.7554/eLife.53392

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