Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu

X-ray crystallography and recombinant protein production have enabled an exponential increase in atomic structures, but often require non-native constructs involving mutations or truncations, and are challenged by membrane proteins and large multi-component complexes. We present here a bottom-up end...

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Detalles Bibliográficos
Autores principales: Ho, Chi-Min, Li, Xiaorun, Lai, Mason, Terwilliger, Thomas C., Beck, Josh R., Wohlschlegel, James, Goldberg, Daniel E., Fitzpatrick, Anthony W. P., Zhou, Z. Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494424/
https://www.ncbi.nlm.nih.gov/pubmed/31768063
http://dx.doi.org/10.1038/s41592-019-0637-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494424/
https://www.ncbi.nlm.nih.gov/pubmed/31768063
http://dx.doi.org/10.1038/s41592-019-0637-y

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