Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

Oxidative stress (OS) in non-alcoholic fatty liver disease (NAFLD) promotes liver injury and inflammation. Treatment with vitamin E (α-tocopherol, αT), a lipid-soluble antioxidant, improves liver injury but also decreases steatosis, thought to be upstream of OS, through an unknown mechanism. To eluc...

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Detalles Bibliográficos
Autores principales: Podszun, Maren C., Alawad, Ahmad S., Lingala, Shilpa, Morris, Nevitt, Huang, Wen-Chun A., Yang, Shanna, Schoenfeld, Megan, Rolt, Adam, Ouwerkerk, Ronald, Valdez, Kristin, Umarova, Regina, Ma, Yanling, Fatima, Syeda Zaheen, Lin, Dennis D., Mahajan, Lakshmi S., Samala, Niharika, Violet, Pierre-Christian, Levine, Mark, Shamburek, Robert, Gharib, Ahmed M., Kleiner, David E., Garraffo, H. Martin, Cai, Hongyi, Walter, Peter J., Rotman, Yaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494510/
https://www.ncbi.nlm.nih.gov/pubmed/32920226
http://dx.doi.org/10.1016/j.redox.2020.101710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494510/
https://www.ncbi.nlm.nih.gov/pubmed/32920226
http://dx.doi.org/10.1016/j.redox.2020.101710

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