A Homodimeric Aptamer Variant Generated from Ligand-Guided Selection Activates the T Cell Receptor Cluster of Differentiation 3 Complex

Recently, immunotherapeutic modalities with engineered cells and monoclonal antibodies have been effective in treating several malignancies. Nucleic acid aptamers can serve as alternative molecules to design immunotherapeutic agents with high functional diversity. Here we report a synthetic prototyp...

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Detalles Bibliográficos
Autores principales: Freage, Lina, Jamal, Deana, Williams, Nicole B., Mallikaratchy, Prabodhika R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494611/
https://www.ncbi.nlm.nih.gov/pubmed/32920262
http://dx.doi.org/10.1016/j.omtn.2020.08.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494611/
https://www.ncbi.nlm.nih.gov/pubmed/32920262
http://dx.doi.org/10.1016/j.omtn.2020.08.016

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