Pharmacological Inhibition of Amyloidogenic APP Processing and Knock-Down of APP in Primary Human Macrophages Impairs the Secretion of Cytokines

It has been previously shown that the amyloid precursor protein (APP) support the innate immune defense as an immune receptor. Amyloid β (Aβ) peptides seem to have properties of an antimicrobial peptide and can act as opsonines. In APP-deficient mouse models, a reduced secretion of cytokines has bee...

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Detalles Bibliográficos
Autores principales: Spitzer, Philipp, Walter, Matthias, Göth, Caroline, Oberstein, Timo Jan, Linning, Philipp, Knölker, Hans-Joachim, Kornhuber, Johannes, Maler, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494750/
https://www.ncbi.nlm.nih.gov/pubmed/33013850
http://dx.doi.org/10.3389/fimmu.2020.01967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494750/
https://www.ncbi.nlm.nih.gov/pubmed/33013850
http://dx.doi.org/10.3389/fimmu.2020.01967

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