Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells

New diagnoses of multiple myeloma (MM) tend to occur after the age of 60, by which time thymic output is severely reduced. As a consequence, lymphocyte recovery after lymphopenia-inducing anti-MM therapies relies on homeostatic proliferation of peripheral T cells rather than replenishment by new thy...

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Detalles Bibliográficos
Autores principales: Cooke, Rachel Elizabeth, Quinn, Kylie Margaret, Quach, Hang, Harrison, Simon, Prince, Henry Miles, Koldej, Rachel, Ritchie, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494758/
https://www.ncbi.nlm.nih.gov/pubmed/33013907
http://dx.doi.org/10.3389/fimmu.2020.02153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494758/
https://www.ncbi.nlm.nih.gov/pubmed/33013907
http://dx.doi.org/10.3389/fimmu.2020.02153

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