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Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells
New diagnoses of multiple myeloma (MM) tend to occur after the age of 60, by which time thymic output is severely reduced. As a consequence, lymphocyte recovery after lymphopenia-inducing anti-MM therapies relies on homeostatic proliferation of peripheral T cells rather than replenishment by new thy...
Autores principales: | Cooke, Rachel Elizabeth, Quinn, Kylie Margaret, Quach, Hang, Harrison, Simon, Prince, Henry Miles, Koldej, Rachel, Ritchie, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494758/ https://www.ncbi.nlm.nih.gov/pubmed/33013907 http://dx.doi.org/10.3389/fimmu.2020.02153 |
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