Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia

HIV-1 associated neurocognitive disorder (HAND) is characterized by neuroinflammation and glial activation that, together with the release of viral proteins, trigger a pathogenic cascade resulting in synaptodendritic damage and neurodegeneration that lead to cognitive impairment. However, the molecu...

Descripción completa

Detalles Bibliográficos
Autores principales: dos Reis, Roberta S., Sant, Shilpa, Keeney, Hannah, Wagner, Marc C. E., Ayyavoo, Velpandi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494890/
https://www.ncbi.nlm.nih.gov/pubmed/32938988
http://dx.doi.org/10.1038/s41598-020-72214-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494890/
https://www.ncbi.nlm.nih.gov/pubmed/32938988
http://dx.doi.org/10.1038/s41598-020-72214-0

Ejemplares similares