The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα–SOD2 pathway

Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote the degradation of cellular proteins in a ubiquitin- and ATP-independent manner. Here, we found that REGγ was significantly upregul...

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Detalles Bibliográficos
Autores principales: Xie, Yifan, Gao, Yang, Gao, Rifeng, Yang, Wenlong, Dong, Zheng, Moses, Robb E., Sun, Aijun, Li, Xiaotao, Ge, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494903/
https://www.ncbi.nlm.nih.gov/pubmed/32424140
http://dx.doi.org/10.1038/s41418-020-0554-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494903/
https://www.ncbi.nlm.nih.gov/pubmed/32424140
http://dx.doi.org/10.1038/s41418-020-0554-8

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