DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

Translation efficiency varies considerably between different mRNAs, thereby impacting protein expression. Translation of the stress response master-regulator ATF4 increases upon stress, but the molecular mechanisms are not well understood. We discover here that translation factors DENR, MCTS1 and eI...

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Detalles Bibliográficos
Autores principales: Bohlen, Jonathan, Harbrecht, Liza, Blanco, Saioa, Clemm von Hohenberg, Katharina, Fenzl, Kai, Kramer, Günter, Bukau, Bernd, Teleman, Aurelio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494916/
https://www.ncbi.nlm.nih.gov/pubmed/32938922
http://dx.doi.org/10.1038/s41467-020-18452-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494916/
https://www.ncbi.nlm.nih.gov/pubmed/32938922
http://dx.doi.org/10.1038/s41467-020-18452-2

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