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Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation
Phosphorylation of the translation initiation factor eIF2α is a rapid and vital response to many forms of stress, including protein-misfolding stress in the endoplasmic reticulum (ER stress). It is believed to cause a general reduction in protein synthesis while enabling translation of few transcrip...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495045/ https://www.ncbi.nlm.nih.gov/pubmed/32937139 http://dx.doi.org/10.1016/j.celrep.2020.108154 |