Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus

AIMS: Racemic ibuprofen is widely used for the treatment of preterm neonates with patent ductus arteriosus. Currently used bodyweight‐based dosing guidelines are based on total ibuprofen, while only the S‐enantiomer of ibuprofen is pharmacologically active. We aimed to optimize ibuprofen dosing for...

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Detalles Bibliográficos
Autores principales: Engbers, Aline G.J., Flint, Robert B., Völler, Swantje, de Klerk, Johan C.A., Reiss, Irwin K.M., Andriessen, Peter, Liem, Kian D., Degraeuwe, Pieter L.J., Croubels, Siska, Millecam, Joske, Allegaert, Karel, Simons, Sinno H.P., Knibbe, Catherijne A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495289/
https://www.ncbi.nlm.nih.gov/pubmed/32250464
http://dx.doi.org/10.1111/bcp.14298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495289/
https://www.ncbi.nlm.nih.gov/pubmed/32250464
http://dx.doi.org/10.1111/bcp.14298

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