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Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus
AIMS: Racemic ibuprofen is widely used for the treatment of preterm neonates with patent ductus arteriosus. Currently used bodyweight‐based dosing guidelines are based on total ibuprofen, while only the S‐enantiomer of ibuprofen is pharmacologically active. We aimed to optimize ibuprofen dosing for...
Autores principales: | Engbers, Aline G.J., Flint, Robert B., Völler, Swantje, de Klerk, Johan C.A., Reiss, Irwin K.M., Andriessen, Peter, Liem, Kian D., Degraeuwe, Pieter L.J., Croubels, Siska, Millecam, Joske, Allegaert, Karel, Simons, Sinno H.P., Knibbe, Catherijne A.J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495289/ https://www.ncbi.nlm.nih.gov/pubmed/32250464 http://dx.doi.org/10.1111/bcp.14298 |
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