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Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks
[Image: see text] A pathway to a range of diverse heterocycles was developed using a nucleophilic cyclization strategy. Lactams and ene-imines are accessed in a few steps from a common precursor, and these moieties are further elaborated to directly provide pyrroles or pyridines with extended conjug...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495751/ https://www.ncbi.nlm.nih.gov/pubmed/32954140 http://dx.doi.org/10.1021/acsomega.0c02282 |
Sumario: | [Image: see text] A pathway to a range of diverse heterocycles was developed using a nucleophilic cyclization strategy. Lactams and ene-imines are accessed in a few steps from a common precursor, and these moieties are further elaborated to directly provide pyrroles or pyridines with extended conjugation. Reaction conditions are mild, and a broad range of structural types are available within a few steps. |
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