Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks

[Image: see text] A pathway to a range of diverse heterocycles was developed using a nucleophilic cyclization strategy. Lactams and ene-imines are accessed in a few steps from a common precursor, and these moieties are further elaborated to directly provide pyrroles or pyridines with extended conjug...

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Autores principales: Fillmore, Brandon C., Price, Jayden, Dean, Ryan, Brown, Amy A., Decken, Andreas, Eisler, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495751/
https://www.ncbi.nlm.nih.gov/pubmed/32954140
http://dx.doi.org/10.1021/acsomega.0c02282
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author Fillmore, Brandon C.
Price, Jayden
Dean, Ryan
Brown, Amy A.
Decken, Andreas
Eisler, Sara
author_facet Fillmore, Brandon C.
Price, Jayden
Dean, Ryan
Brown, Amy A.
Decken, Andreas
Eisler, Sara
author_sort Fillmore, Brandon C.
collection PubMed
description [Image: see text] A pathway to a range of diverse heterocycles was developed using a nucleophilic cyclization strategy. Lactams and ene-imines are accessed in a few steps from a common precursor, and these moieties are further elaborated to directly provide pyrroles or pyridines with extended conjugation. Reaction conditions are mild, and a broad range of structural types are available within a few steps.
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spelling pubmed-74957512020-09-18 Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks Fillmore, Brandon C. Price, Jayden Dean, Ryan Brown, Amy A. Decken, Andreas Eisler, Sara ACS Omega [Image: see text] A pathway to a range of diverse heterocycles was developed using a nucleophilic cyclization strategy. Lactams and ene-imines are accessed in a few steps from a common precursor, and these moieties are further elaborated to directly provide pyrroles or pyridines with extended conjugation. Reaction conditions are mild, and a broad range of structural types are available within a few steps. American Chemical Society 2020-09-02 /pmc/articles/PMC7495751/ /pubmed/32954140 http://dx.doi.org/10.1021/acsomega.0c02282 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Fillmore, Brandon C.
Price, Jayden
Dean, Ryan
Brown, Amy A.
Decken, Andreas
Eisler, Sara
Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks
title Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks
title_full Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks
title_fullStr Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks
title_full_unstemmed Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks
title_short Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks
title_sort accessing the ene–imine motif in 1h-isoindole, thienopyrrole, and thienopyridine building blocks
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495751/
https://www.ncbi.nlm.nih.gov/pubmed/32954140
http://dx.doi.org/10.1021/acsomega.0c02282
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