XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity

BACKGROUND: XMU-MP-1 is an inhibitor of the Hippo pathway kinases MST1/2 and has been shown to promote the downstream activation of the pro-proliferative, pro-regenerative and anti-apoptotic transcriptional regulator YAP1. We tested whether XMU-MP-1 can activate YAP1 in a model human mini-organ, nam...

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Detalles Bibliográficos
Autores principales: Mitchell, Ellen, Mellor, Charlotte E. L., Purba, Talveen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495873/
https://www.ncbi.nlm.nih.gov/pubmed/32973917
http://dx.doi.org/10.1186/s13008-020-00067-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495873/
https://www.ncbi.nlm.nih.gov/pubmed/32973917
http://dx.doi.org/10.1186/s13008-020-00067-0

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