Inter-laboratory study of an optimised peptide mapping workflow using automated trypsin digestion for monitoring monoclonal antibody product quality attributes

Peptide mapping analysis is a regulatory expectation to verify the primary structure of a recombinant product sequence and to monitor post-translational modifications (PTMs). Although proteolytic digestion has been used for decades, it remains a labour-intensive procedure that can be challenging to...

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Detalles Bibliográficos
Autores principales: Millán-Martín, Silvia, Jakes, Craig, Carillo, Sara, Buchanan, Tom, Guender, Marc, Kristensen, Dan Bach, Sloth, Trine Meiborg, Ørgaard, Martin, Cook, Ken, Bones, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496030/
https://www.ncbi.nlm.nih.gov/pubmed/32710279
http://dx.doi.org/10.1007/s00216-020-02809-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496030/
https://www.ncbi.nlm.nih.gov/pubmed/32710279
http://dx.doi.org/10.1007/s00216-020-02809-z

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