Olaparib‐Based Photoaffinity Probes for PARP‐1 Detection in Living Cells

The poly‐ADP‐ribose polymerase (PARP) is a protein from the family of ADP‐ribosyltransferases that catalyzes polyadenosine diphosphate ribose (ADPR) formation in order to attract the DNA repair machinery to sites of DNA damage. The inhibition of PARP activity by olaparib can cause cell death, which...

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Detalles Bibliográficos
Autores principales: Voorneveld, Jim, Florea, Bogdan I., Bakkum, Thomas, Mendowicz, Rafal J., van der Veer, Miriam S., Gagestein, Berend, van Kasteren, Sander I., van der Stelt, Mario, Overkleeft, Herman S., Filippov, Dmitri V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496120/
https://www.ncbi.nlm.nih.gov/pubmed/32282108
http://dx.doi.org/10.1002/cbic.202000042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496120/
https://www.ncbi.nlm.nih.gov/pubmed/32282108
http://dx.doi.org/10.1002/cbic.202000042

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