Explicit representation of protein activity states significantly improves causal discovery of protein phosphorylation networks

BACKGROUND: Protein phosphorylation networks play an important role in cell signaling. In these networks, phosphorylation of a protein kinase usually leads to its activation, which in turn will phosphorylate its downstream target proteins. A phosphorylation network is essentially a causal network, w...

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Detalles Bibliográficos
Autores principales: Liu, Jinling, Ma, Xiaojun, Cooper, Gregory F., Lu, Xinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496209/
https://www.ncbi.nlm.nih.gov/pubmed/32938361
http://dx.doi.org/10.1186/s12859-020-03676-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496209/
https://www.ncbi.nlm.nih.gov/pubmed/32938361
http://dx.doi.org/10.1186/s12859-020-03676-2

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