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Explicit representation of protein activity states significantly improves causal discovery of protein phosphorylation networks
BACKGROUND: Protein phosphorylation networks play an important role in cell signaling. In these networks, phosphorylation of a protein kinase usually leads to its activation, which in turn will phosphorylate its downstream target proteins. A phosphorylation network is essentially a causal network, w...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496209/ https://www.ncbi.nlm.nih.gov/pubmed/32938361 http://dx.doi.org/10.1186/s12859-020-03676-2 |