Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells

A novel class of glutathione peroxidase 1 (GPx1) inhibitors, namely tri‐ and tetracyclic pentathiepins, has been identified that is approximately 15 times more potent than the most active known GPx1 inhibitor, mercaptosuccinic acid. Enzyme kinetic studies with bovine erythrocyte GPx1 indicate that p...

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Detalles Bibliográficos
Autores principales: Behnisch‐Cornwell, Steven, Bandaru, Siva Sankar Murthy, Napierkowski, Martin, Wolff, Lisa, Zubair, Muhammad, Urbainsky, Claudia, Lillig, Christopher, Schulzke, Carola, Bednarski, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496275/
https://www.ncbi.nlm.nih.gov/pubmed/32311219
http://dx.doi.org/10.1002/cmdc.202000160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496275/
https://www.ncbi.nlm.nih.gov/pubmed/32311219
http://dx.doi.org/10.1002/cmdc.202000160

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