Cargando…

Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells

A novel class of glutathione peroxidase 1 (GPx1) inhibitors, namely tri‐ and tetracyclic pentathiepins, has been identified that is approximately 15 times more potent than the most active known GPx1 inhibitor, mercaptosuccinic acid. Enzyme kinetic studies with bovine erythrocyte GPx1 indicate that p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Behnisch‐Cornwell, Steven, Bandaru, Siva Sankar Murthy, Napierkowski, Martin, Wolff, Lisa, Zubair, Muhammad, Urbainsky, Claudia, Lillig, Christopher, Schulzke, Carola, Bednarski, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496275/ https://www.ncbi.nlm.nih.gov/pubmed/32311219 http://dx.doi.org/10.1002/cmdc.202000160

Ejemplares similares

Comprehensive Evaluation of Biological Effects of Pentathiepins on Various Human Cancer Cell Lines and Insights into Their Mode of Action
por: Wolff, Lisa, et al.
Publicado: (2021)

The Effect of Glutathione Peroxidase-1 Knockout on Anticancer Drug Sensitivities and Reactive Oxygen Species in Haploid HAP-1 Cells
por: Behnisch-Cornwell, Steven, et al.
Publicado: (2020)

Synthesis of 9-arylalkynyl- and 9-aryl-substituted benzo[b]quinolizinium derivatives by Palladium-mediated cross-coupling reactions
por: Bandaru, Siva Sankar Murthy, et al.
Publicado: (2018)

Crystal structure of 4-(pyrazin-2-yl)morpholine
por: Bandaru, Siva Sankar Murthy, et al.
Publicado: (2018)

Synthesis and Identification of Pentathiepin-Based Inhibitors of Sporothrix brasiliensis
por: Asquith, Christopher R. M., et al.
Publicado: (2019)

Glutathione peroxidases as oncotargets
por: Jiao, Yang, et al.
Publicado: (2017)

The Mechanism of Metal-Containing Formate Dehydrogenases Revisited: The Formation of Bicarbonate as Product Intermediate Provides Evidence for an Oxygen Atom Transfer Mechanism
por: Kumar, Hemant, et al.
Publicado: (2023)

Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics
por: Hu, Wenhui, et al.
Publicado: (2023)

Self-assembled, hemin-functionalized peptide nanotubes: an innovative strategy for detecting glutathione and glucose molecules with peroxidase-like activity
por: Xiang, Song, et al.
Publicado: (2023)

Long noncoding RNA glutathione peroxidase 3–antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract
por: Tu, Yuanyuan, et al.
Publicado: (2019)

Expression of glutathione, glutathione peroxidase and glutathione S-transferase pi in canine mammary tumors
por: Leonel, Camila, et al.
Publicado: (2014)

The Roles of Glutathione Peroxidases during Embryo Development
por: Ufer, Christoph, et al.
Publicado: (2011)

Function of glutathione peroxidases in legume root nodules
por: Matamoros, Manuel A., et al.
Publicado: (2015)

Evaluation of Glutathione Peroxidase 4 role in Preeclampsia
por: Peng, Xinguo, et al.
Publicado: (2016)

Redox regulation by glutathione needs enzymes
por: Berndt, Carsten, et al.
Publicado: (2014)

Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk
por: Méplan, Catherine, et al.
Publicado: (2013)

Decreased Cardiac Glutathione Peroxidase Levels and Enhanced Mandibular Apoptosis in Malformed Embryos of Diabetic Rats
por: Wentzel, Parri, et al.
Publicado: (2008)

Control of doxorubicin-induced, reactive oxygen-related apoptosis by glutathione peroxidase 1 in cardiac fibroblasts
por: Doroshow, James H., et al.
Publicado: (2019)

Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility
por: Grathwol, Christoph W., et al.
Publicado: (2020)

Erythrocyte glutathione peroxidase (GSH-Px) polymorphism in Finnsheep
por: Atroshi, F, et al.
Publicado: (1982)

Glutathione peroxidase and malondialdehyde in children with chronic hepatitis C
por: Khedr, Mohammed Ahmed, et al.
Publicado: (2019)

Genetic Polymorphisms of Catalase and Glutathione Peroxidase-1 in Keratoconus
por: YARI, Davood, et al.
Publicado: (2018)

Feasible Relation between Glutathione Peroxidase and Febrile Seizure
por: MAHYAR, Abolfazl, et al.
Publicado: (2017)

Involvement of glutathione peroxidases in the occurrence and development of breast cancers
por: Zhang, Man-Li, et al.
Publicado: (2020)

The clinical significance of glutathione peroxidase 2 in glioblastoma multiforme
por: Guo, Bangming, et al.
Publicado: (2021)

Peroxidase catalytic activity of carbon nanoparticles for glutathione detection
por: Chen, Lijuan, et al.
Publicado: (2021)

Research progress of glutathione peroxidase family (GPX) in redoxidation
por: Pei, Jun, et al.
Publicado: (2023)

The contribution of glutathione peroxidases to chloroplast redox homeostasis in Arabidopsis
por: Casatejada, Azahara, et al.
Publicado: (2023)

Evaluation of saliva glutathione, glutathione peroxidase, and malondialdehyde levels in head-neck radiotherapy patients
por: DERİNDAĞ, Gözde, et al.
Publicado: (2021)

Radiation affects glutathione redox reaction by reduced glutathione peroxidase activity in human fibroblasts
por: Shimura, Tsutomu, et al.
Publicado: (2021)

Pharmacological Evaluation of the Anticancer Activity of Extracts and Fractions of Lannea barteri Oliv. (Anacardiaceae) on Adherent Human Cancer Cell Lines
por: Mbaoji, Florence N., et al.
Publicado: (2020)

Stress-Based Production, and Characterization of Glutathione Peroxidase and Glutathione S-Transferase Enzymes From Lactobacillus plantarum
por: Al-Madboly, Lamiaa A., et al.
Publicado: (2020)

Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis
por: Xiao, Bi-huan, et al.
Publicado: (2016)

Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina
por: Sakai, Osamu, et al.
Publicado: (2015)

Possibility of using superoxide dismutase and glutathione peroxidase as endometriosis biomarkers
por: Ekarattanawong, Sophapun, et al.
Publicado: (2017)

Blood Glutathione Peroxidase Activity in Patients with Osteoarthritis Treated with Oxicams
por: AMZOIU, D.C., et al.
Publicado: (2016)

Phenylselanyl Group Incorporation for “Glutathione Peroxidase-Like” Activity Modulation
por: Obieziurska-Fabisiak, Magdalena, et al.
Publicado: (2020)

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer
por: Chang, Caroline, et al.
Publicado: (2020)

Glutathione Peroxidase GPX1 and Its Dichotomous Roles in Cancer
por: Zhao, Yangjing, et al.
Publicado: (2022)

Decreased Activity of Erythrocyte Catalase and Glutathione Peroxidase in Patients with Schizophrenia
por: Djordjević, Vladimir V., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_19pheepdndfcaeh47mnla4aj7r