Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8(+) T cells

Adoptive T cell transfer therapy induces objective responses in patients with advanced malignancies. Despite these results, some individuals do not respond due to the generation of terminally differentiated T cells during the expansion protocol. As the gamma and delta catalytic subunits in the PI3K...

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Detalles Bibliográficos
Autores principales: Dwyer, Connor J., Arhontoulis, Dimitrios C., Rangel Rivera, Guillermo O, Knochelmann, Hannah M., Smith, Aubrey S., Wyatt, Megan M., Rubinstein, Mark P., Atkinson, Carl, Thaxton, Jessica E., Neskey, David M., Paulos, Chrystal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Tumor immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496332/
https://www.ncbi.nlm.nih.gov/pubmed/32383488
http://dx.doi.org/10.1002/eji.201948455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496332/
https://www.ncbi.nlm.nih.gov/pubmed/32383488
http://dx.doi.org/10.1002/eji.201948455

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