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Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages

Derivatives of 4‐aminomethyl‐l‐phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C‐terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results e...

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Detalles Bibliográficos
Autores principales: Tsiamantas, Christos, Kwon, Sunbum, Rogers, Joseph M., Douat, Céline, Huc, Ivan, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496375/
https://www.ncbi.nlm.nih.gov/pubmed/31894626
http://dx.doi.org/10.1002/anie.201914654