Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages

Derivatives of 4‐aminomethyl‐l‐phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C‐terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results e...

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Detalles Bibliográficos
Autores principales: Tsiamantas, Christos, Kwon, Sunbum, Rogers, Joseph M., Douat, Céline, Huc, Ivan, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496375/
https://www.ncbi.nlm.nih.gov/pubmed/31894626
http://dx.doi.org/10.1002/anie.201914654
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author Tsiamantas, Christos
Kwon, Sunbum
Rogers, Joseph M.
Douat, Céline
Huc, Ivan
Suga, Hiroaki
author_facet Tsiamantas, Christos
Kwon, Sunbum
Rogers, Joseph M.
Douat, Céline
Huc, Ivan
Suga, Hiroaki
author_sort Tsiamantas, Christos
collection PubMed
description Derivatives of 4‐aminomethyl‐l‐phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C‐terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.
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spelling pubmed-74963752020-09-25 Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages Tsiamantas, Christos Kwon, Sunbum Rogers, Joseph M. Douat, Céline Huc, Ivan Suga, Hiroaki Angew Chem Int Ed Engl Communications Derivatives of 4‐aminomethyl‐l‐phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C‐terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated. John Wiley and Sons Inc. 2020-02-04 2020-03-16 /pmc/articles/PMC7496375/ /pubmed/31894626 http://dx.doi.org/10.1002/anie.201914654 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Tsiamantas, Christos
Kwon, Sunbum
Rogers, Joseph M.
Douat, Céline
Huc, Ivan
Suga, Hiroaki
Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages
title Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages
title_full Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages
title_fullStr Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages
title_full_unstemmed Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages
title_short Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages
title_sort ribosomal incorporation of aromatic oligoamides as peptide sidechain appendages
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496375/
https://www.ncbi.nlm.nih.gov/pubmed/31894626
http://dx.doi.org/10.1002/anie.201914654
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