Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti‐CD74 autoantibodies in human ankylosing spondylitis

Ankylosing spondylitis (AS) is associated with autoantibody production to class II MHC‐associated invariant chain peptide, CD74/CLIP. In this study, we considered that anti‐CD74/CLIP autoantibodies present in sera from AS might recognize CD74 degradation products that accumulate upon deficiency of t...

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Detalles Bibliográficos
Autores principales: van Kempen, Tessa S., Leijten, Emmerik F.A., Lindenbergh, Marthe F.S., Nordkamp, Michel Olde, Driessen, Christoph, Lebbink, Robert‐Jan, Baerlecken, Niklas, Witte, Torsten, Radstake, Timothy R.D.J., Boes, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Immunodeficiencies and autoimmunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496470/
https://www.ncbi.nlm.nih.gov/pubmed/32198923
http://dx.doi.org/10.1002/eji.201948502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496470/
https://www.ncbi.nlm.nih.gov/pubmed/32198923
http://dx.doi.org/10.1002/eji.201948502

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