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Common Variants Coregulate Expression of GBA and Modifier Genes to Delay Parkinson's Disease Onset

BACKGROUND: GBA mutations are numerically the most significant genetic risk factor for Parkinson's disease (PD), yet these mutations have low penetrance, suggesting additional mechanisms. OBJECTIVES: The objective of this study was to determine if the penetrance of GBA in PD can be explained by...

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Detalles Bibliográficos
Autores principales: Schierding, William, Farrow, Sophie, Fadason, Tayaza, Graham, Oscar E.E., Pitcher, Toni L., Qubisi, Sara, Davidson, Alan J., Perry, Jo K., Anderson, Tim J., Kennedy, Martin A., Cooper, Antony, O'Sullivan, Justin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496525/
https://www.ncbi.nlm.nih.gov/pubmed/32557794
http://dx.doi.org/10.1002/mds.28144