Single‐Molecule Observation of Intermediates in Bioorthogonal 2‐Cyanobenzothiazole Chemistry

We report a single‐molecule mechanistic investigation into 2‐cyanobenzothiazole (CBT) chemistry within a protein nanoreactor. When simple thiols reacted reversibly with CBT, the thioimidate monoadduct was approximately 80‐fold longer‐lived than the tetrahedral bisadduct, with important implications...

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Detalles Bibliográficos
Autores principales: Qing, Yujia, Liu, Mira D., Hartmann, Denis, Zhou, Linna, Ramsay, William J., Bayley, Hagan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496719/
https://www.ncbi.nlm.nih.gov/pubmed/32589803
http://dx.doi.org/10.1002/anie.202005729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496719/
https://www.ncbi.nlm.nih.gov/pubmed/32589803
http://dx.doi.org/10.1002/anie.202005729

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