Understanding Substrate Selectivity of Phoslactomycin Polyketide Synthase by Using Reconstituted in Vitro Systems

Polyketide synthases (PKSs) use simple extender units to synthesize complex natural products. A fundamental question is how different extender units are site‐specifically incorporated into the growing polyketide. Here we established phoslactomycin (Pn) PKS, which incorporates malonyl‐ and ethylmalon...

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Detalles Bibliográficos
Autores principales: Geyer, Kyra, Sundaram, Srividhya, Sušnik, Peter, Koert, Ulrich, Erb, Tobias J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496768/
https://www.ncbi.nlm.nih.gov/pubmed/32227577
http://dx.doi.org/10.1002/cbic.202000112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496768/
https://www.ncbi.nlm.nih.gov/pubmed/32227577
http://dx.doi.org/10.1002/cbic.202000112

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