Characterizing the original anti‐C5 function‐blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5

The implication of complement in multiple diseases over the last 20 years has fuelled interest in developing anti‐complement drugs. To date, the focus has been on C5; blocking cleavage of C5 prevents formation of two pro‐inflammatory activities, C5a anaphylatoxin and membrane attack complex. The con...

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Detalles Bibliográficos
Autores principales: Zelek, Wioleta M., Menzies, Georgina E., Brancale, Andrea, Stockinger, Brigitta, Morgan, Bryan Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496778/
https://www.ncbi.nlm.nih.gov/pubmed/32557571
http://dx.doi.org/10.1111/imm.13228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496778/
https://www.ncbi.nlm.nih.gov/pubmed/32557571
http://dx.doi.org/10.1111/imm.13228

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