Biological Characterization, Mechanistic Investigation and Structure‐Activity Relationships of Chemically Stable TLR2 Antagonists

Toll‐like receptors (TLRs) build the first barrier in the innate immune response and therefore represent promising targets for the modulation of inflammatory processes. Recently, the pyrogallol‐containing TLR2 antagonists CU‐CPT22 and MMG‐11 were reported; however, their 1,2,3‐triphenol motif render...

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Detalles Bibliográficos
Autores principales: Bermudez, Marcel, Grabowski, Maria, Murgueitio, Manuela S., Tiemann, Markus, Varga, Péter, Rudolf, Thomas, Wolber, Gerhard, Weindl, Günther, Rademann, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496872/
https://www.ncbi.nlm.nih.gov/pubmed/32333508
http://dx.doi.org/10.1002/cmdc.202000060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496872/
https://www.ncbi.nlm.nih.gov/pubmed/32333508
http://dx.doi.org/10.1002/cmdc.202000060

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