Enantioselective Synthesis of α‐Thiocarboxylic Acids by Nitrilase Biocatalysed Dynamic Kinetic Resolution of α‐Thionitriles

The enantioselective synthesis of α‐thiocarboxylic acids by biocatalytic dynamic kinetic resolution (DKR) of nitrile precursors exploiting nitrilase enzymes is described. A panel of 35 nitrilase biocatalysts were screened and enzymes Nit27 and Nit34 were found to catalyse the DKR of racemic α‐thioni...

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Detalles Bibliográficos
Autores principales: Lauder, Kate, Anselmi, Silvia, Finnigan, James D., Qi, Yuyin, Charnock, Simon J., Castagnolo, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496879/
https://www.ncbi.nlm.nih.gov/pubmed/32239730
http://dx.doi.org/10.1002/chem.202001108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496879/
https://www.ncbi.nlm.nih.gov/pubmed/32239730
http://dx.doi.org/10.1002/chem.202001108

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