Cargando…

Enantioselective Synthesis of α‐Thiocarboxylic Acids by Nitrilase Biocatalysed Dynamic Kinetic Resolution of α‐Thionitriles

The enantioselective synthesis of α‐thiocarboxylic acids by biocatalytic dynamic kinetic resolution (DKR) of nitrile precursors exploiting nitrilase enzymes is described. A panel of 35 nitrilase biocatalysts were screened and enzymes Nit27 and Nit34 were found to catalyse the DKR of racemic α‐thioni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lauder, Kate, Anselmi, Silvia, Finnigan, James D., Qi, Yuyin, Charnock, Simon J., Castagnolo, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496879/ https://www.ncbi.nlm.nih.gov/pubmed/32239730 http://dx.doi.org/10.1002/chem.202001108

Ejemplares similares

Biocatalysed synthesis planning using data-driven learning
por: Probst, Daniel, et al.
Publicado: (2022)

Biosynthesis of thiocarboxylic acid-containing natural products
por: Dong, Liao-Bin, et al.
Publicado: (2018)

Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
por: Dinica, Rodica Mihaela, et al.
Publicado: (2013)

Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides
por: Anselmi, Silvia, et al.
Publicado: (2023)

Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides
por: Anselmi, Silvia, et al.
Publicado: (2020)

Plant Nitrilase Homologues in Fungi: Phylogenetic and Functional Analysis with Focus on Nitrilases in Trametes versicolor and Agaricus bisporus
por: Rucká, Lenka, et al.
Publicado: (2020)

Kinetic Resolution of Racemic Mixtures via Enantioselective Photocatalysis
por: Arbell, Nitai, et al.
Publicado: (2021)

The nitrilase superfamily: classification, structure and function
por: Pace, Helen C, et al.
Publicado: (2001)

Genetic and Functional Diversity of Nitrilases in Agaricomycotina
por: Rucká, Lenka, et al.
Publicado: (2019)

Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis †
por: Perdicchia, Dario, et al.
Publicado: (2015)

Nitrilase enzymes and their role in plant–microbe interactions
por: Howden, Andrew J. M., et al.
Publicado: (2009)

Photocontrolled reversible self-assembly of dodecamer nitrilase
por: Yu, Qiao, et al.
Publicado: (2017)

Mining of Microbial Genomes for the Novel Sources of Nitrilases
por: Sharma, Nikhil, et al.
Publicado: (2017)

Enantioselective preparation of mechanically planar chiral rotaxanes by kinetic resolution strategy
por: Imayoshi, Ayumi, et al.
Publicado: (2021)

Iridium-catalyzed enantioselective alkynylation and kinetic resolution of alkyl allylic alcohols
por: Guo, Jia, et al.
Publicado: (2022)

Organocatalytic Enantioselective α-Nitrogenation of α,α-Disubstituted Aldehydes in the Absence of a Solvent
por: Torregrosa-Chinillach, Alejandro, et al.
Publicado: (2022)

Rhodium-catalyzed enantioselective C–H alkynylation of sulfoxides in diverse patterns: desymmetrization, kinetic resolution, and parallel kinetic resolution
por: Kong, Lingheng, et al.
Publicado: (2022)

Nitrilases in nitrile biocatalysis: recent progress and forthcoming research
por: Gong, Jin-Song, et al.
Publicado: (2012)

Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats
por: Uchida, Ryota, et al.
Publicado: (2015)

Enantioselective kinetic resolution of phenylalkyl carboxylic acids using metagenome‐derived esterases
por: Fernández‐Álvaro, Elena, et al.
Publicado: (2010)

Enantioselective Formal α‐Methylation and α‐Benzylation of Aldehydes by Means of Photo‐organocatalysis
por: Filippini, Giacomo, et al.
Publicado: (2017)

Enantioselective organocatalytic syntheses of α-selenated α- and β-amino acid derivatives
por: Haider, Victoria, et al.
Publicado: (2022)

Organocatalytic asymmetric fluorination of α-chloroaldehydes involving kinetic resolution
por: Shibatomi, Kazutaka, et al.
Publicado: (2014)

Response surface methodology of nitrilase production by recombinant Escherichia coli
por: Dubey, Sachin, et al.
Publicado: (2011)

A New Thermophilic Nitrilase from an Antarctic Hyperthermophilic Microorganism
por: Dennett, Geraldine V., et al.
Publicado: (2016)

Nitrilase 1 modulates lung tumor progression in vitro and in vivo
por: Wang, Yong Antican, et al.
Publicado: (2016)

Substrate specificity of plant nitrilase complexes is affected by their helical twist
por: Woodward, Jeremy D., et al.
Publicado: (2018)

From sequence to function: a new workflow for nitrilase identification
por: Egelkamp, Richard, et al.
Publicado: (2020)

Enantioselective conjugate hydrosilylation of α,β-unsaturated ketones
por: Yang, Huan, et al.
Publicado: (2019)

Organocatalytic Enantioselective α-Bromination of Aldehydes with N-Bromosuccinimide
por: Hutchinson, George, et al.
Publicado: (2022)

Catalytic Enantioselective Synthesis of α-Difunctionalized Cyclic Sulfones
por: Bowen, Eleanor, et al.
Publicado: (2022)

Enantioselective Giese Additions of Prochiral α-Amino Radicals
por: Lahdenperä, Antti S. K., et al.
Publicado: (2022)

Catalytic photochemical enantioselective α-alkylation with pyridinium salts
por: Yetra, Santhivardhana Reddy, et al.
Publicado: (2022)

Isothiourea‐Catalyzed Acylative Kinetic Resolution of Tertiary α‐Hydroxy Esters
por: Qu, Shen, et al.
Publicado: (2020)

Asymmetric α-spirocyclopropanation of oxindoles and benzofuranones via dynamic kinetic resolution
por: Hu, Yang, et al.
Publicado: (2022)

Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies
por: El-Azab, Adel S., et al.
Publicado: (2018)

The Uba4 domain interplay is mediated via a thioester that is critical for tRNA thiolation through Urm1 thiocarboxylation
por: Termathe, Martin, et al.
Publicado: (2018)

Screening and Improving the Recombinant Nitrilases and Application in Biotransformation of Iminodiacetonitrile to Iminodiacetic Acid
por: Liu, Zhi-Qiang, et al.
Publicado: (2013)

Enantioselective Synthesis of Chromanones Bearing an α,α-Disubstituted α-Amino Acid Moiety via Decarboxylative Michael Reaction
por: Bojanowski, Jan, et al.
Publicado: (2019)

Enantioselective synthesis of α-alkenyl α-amino acids via N–H insertion reactions
por: Guo, Jun-Xia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_61a6ac08k7q6vradr8sfovr5ul