PI by NMR: Probing CH–π Interactions in Protein–Ligand Complexes by NMR Spectroscopy

While CH–π interactions with target proteins are crucial determinants for the affinity of arguably every drug molecule, no method exists to directly measure the strength of individual CH–π interactions in drug–protein complexes. Herein, we present a fast and reliable methodology called PI (π interac...

Descripción completa

Detalles Bibliográficos
Autores principales: Platzer, Gerald, Mayer, Moriz, Beier, Andreas, Brüschweiler, Sven, Fuchs, Julian E., Engelhardt, Harald, Geist, Leonhard, Bader, Gerd, Schörghuber, Julia, Lichtenecker, Roman, Wolkerstorfer, Bernhard, Kessler, Dirk, McConnell, Darryl B., Konrat, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496880/
https://www.ncbi.nlm.nih.gov/pubmed/32421895
http://dx.doi.org/10.1002/anie.202003732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496880/
https://www.ncbi.nlm.nih.gov/pubmed/32421895
http://dx.doi.org/10.1002/anie.202003732

Ejemplares similares