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Alteration of the Conformational Dynamics of a DNA Hairpin by α‐Synuclein in the Presence of Aqueous Two‐Phase Systems

The effect of an amyloidogenic intrinsically disordered protein, α‐synuclein, which is associated with Parkinson's disease (PD), on the conformational dynamics of a DNA hairpin (DNA‐HP) was studied by employing the single‐molecule Förster resonance energy transfer method. The open‐to‐closed con...

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Detalles Bibliográficos
Autores principales: Mukherjee, Sanjib K., Knop, Jim‐Marcel, Möbitz, Simone, Winter, Roland H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496936/
https://www.ncbi.nlm.nih.gov/pubmed/32453478
http://dx.doi.org/10.1002/chem.202002119