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Anatomical similarity between the Sost‐knockout mouse and sclerosteosis in humans

Sclerosteosis, a rare autosomal recessive genetic disorder caused by a mutation of the Sost gene, manifests in the facial skeleton by gigantism, facial distortion, mandibular prognathism, cranial nerve palsy, and, in extreme cases, compression of the medulla oblongata. Mice lacking sclerostin reflec...

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Detalles Bibliográficos
Autores principales: Schwarze, Uwe Y., Dobsak, Toni, Gruber, Reinhard, Bookstein, Fred L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496997/
https://www.ncbi.nlm.nih.gov/pubmed/31729194
http://dx.doi.org/10.1002/ar.24318