The Human Host‐Defense Peptide Cathelicidin LL‐37 is a Nanomolar Inhibitor of Amyloid Self‐Assembly of Islet Amyloid Polypeptide (IAPP)

Amyloid self‐assembly of islet amyloid polypeptide (IAPP) is linked to pancreatic inflammation, β‐cell degeneration, and the pathogenesis of type 2 diabetes (T2D). The multifunctional host‐defence peptides (HDPs) cathelicidins play crucial roles in inflammation. Here, we show that the antimicrobial...

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Detalles Bibliográficos
Autores principales: Armiento, Valentina, Hille, Kathleen, Naltsas, Denise, Lin, Jennifer S., Barron, Annelise E., Kapurniotu, Aphrodite
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497016/
https://www.ncbi.nlm.nih.gov/pubmed/31999880
http://dx.doi.org/10.1002/anie.202000148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497016/
https://www.ncbi.nlm.nih.gov/pubmed/31999880
http://dx.doi.org/10.1002/anie.202000148

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