Cargando…

The Human Host‐Defense Peptide Cathelicidin LL‐37 is a Nanomolar Inhibitor of Amyloid Self‐Assembly of Islet Amyloid Polypeptide (IAPP)

Amyloid self‐assembly of islet amyloid polypeptide (IAPP) is linked to pancreatic inflammation, β‐cell degeneration, and the pathogenesis of type 2 diabetes (T2D). The multifunctional host‐defence peptides (HDPs) cathelicidins play crucial roles in inflammation. Here, we show that the antimicrobial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Armiento, Valentina, Hille, Kathleen, Naltsas, Denise, Lin, Jennifer S., Barron, Annelise E., Kapurniotu, Aphrodite
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497016/ https://www.ncbi.nlm.nih.gov/pubmed/31999880 http://dx.doi.org/10.1002/anie.202000148

Ejemplares similares

Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide
por: Rezaei-Ghaleh, Nasrollah, et al.
Publicado: (2011)

Myricetin Inhibits Islet Amyloid Polypeptide (IAPP) Aggregation and Rescues Living Mammalian Cells from IAPP Toxicity
por: Zelus, Casey, et al.
Publicado: (2012)

Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action
por: Niu, Zheng, et al.
Publicado: (2020)

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
por: Mishra, Aseem, et al.
Publicado: (2013)

β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation
por: Lesma, Jacopo, et al.
Publicado: (2021)

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice
por: Franko, Andras, et al.
Publicado: (2018)

Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies
por: Moore, Sandra J., et al.
Publicado: (2018)

Pulmonary defense and the human cathelicidin hCAP-18/LL-37
por: Fahy, R. J., et al.
Publicado: (2005)

Unfolding Novel Mechanisms of Polyphenol Flavonoids for Better Glycaemic Control: Targeting Pancreatic Islet Amyloid Polypeptide (IAPP)
por: Sequeira, Ivana R., et al.
Publicado: (2017)

Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes
por: Bortoletto, Angelina S., et al.
Publicado: (2022)

BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells
por: Oskarsson, Marie E., et al.
Publicado: (2018)

The Role of Cathelicidin LL-37 in Cancer Development
por: Piktel, Ewelina, et al.
Publicado: (2015)

Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly
por: Taş, Karin, et al.
Publicado: (2022)

Adsorption and Orientation of Human Islet Amyloid Polypeptide (hIAPP) Monomer at Anionic Lipid Bilayers: Implications for Membrane-Mediated Aggregation
por: Jia, Yan, et al.
Publicado: (2013)

Cathelicidin LL-37 in Health and Diseases of the Oral Cavity
por: Tokajuk, Joanna, et al.
Publicado: (2022)

Human Islet Amyloid Polypeptide Transgenic Mice: In Vivo and Ex Vivo Models for the Role of hIAPP in Type 2 Diabetes Mellitus
por: Höppener, J. W. M., et al.
Publicado: (2008)

Exploring the Influence of EGCG on the β-Sheet-Rich Oligomers of Human Islet Amyloid Polypeptide (hIAPP(1–37)) and Identifying Its Possible Binding Sites from Molecular Dynamics Simulation
por: Wang, Qianqian, et al.
Publicado: (2014)

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37
por: Barlow, Peter G., et al.
Publicado: (2011)

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
por: Shih, Alexis Z.L., et al.
Publicado: (2022)

The Amyloid Forming Peptides Islet Amyloid Polypeptide and Amyloid β Interact at the Molecular Level
por: Wang, Ye, et al.
Publicado: (2021)

Structural Similarities and Differences between Amyloidogenic and Non-Amyloidogenic Islet Amyloid Polypeptide (IAPP) Sequences and Implications for the Dual Physiological and Pathological Activities of These Peptides
por: Wu, Chun, et al.
Publicado: (2013)

Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
por: Bortoletto, Angelina S., et al.
Publicado: (2022)

Bleomycin modulates amyloid aggregation in β-amyloid and hIAPP
por: Kumari, Anchala, et al.
Publicado: (2020)

The Role of the 14–20 Domain of the Islet Amyloid Polypeptide in Amyloid Formation
por: Gilead, Sharon, et al.
Publicado: (2008)

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology
por: Akter, Rehana, et al.
Publicado: (2016)

Efficacy of Cathelicidin LL-37 in an MRSA Wound Infection Mouse Model
por: Simonetti, Oriana, et al.
Publicado: (2021)

Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation
por: Wasana Jayaweera, Sanduni, et al.
Publicado: (2021)

The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide
por: Christensen, Mikkel, et al.
Publicado: (2021)

Studies on alpha-synuclein and islet amyloid polypeptide interaction
por: Wang, Ye, et al.
Publicado: (2023)

Islet amyloid polypeptide does not suppress pancreatic cancer
por: Taylor, Austin J., et al.
Publicado: (2023)

On the plasticity of amyloid formation: The impact of destabilizing small to large substitutions on islet amyloid polypeptide amyloid formation
por: Manathunga, Lakshan, et al.
Publicado: (2023)

Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis
por: Aloul, Karim M., et al.
Publicado: (2022)

Diabetes Drug Discovery: hIAPP(1–37) Polymorphic Amyloid Structures as Novel Therapeutic Targets
por: Fernández-Gómez, Isaac, et al.
Publicado: (2018)

Defining the Molecular Basis of Amyloid Inhibitors: Human Islet Amyloid Polypeptide–Insulin Interactions
por: Susa, Anna C., et al.
Publicado: (2014)

Inhibitory effects of choline-O-sulfate on amyloid formation of human islet amyloid polypeptide
por: Hagihara, Mamoru, et al.
Publicado: (2012)

Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide
por: Jean, Létitia, et al.
Publicado: (2016)

Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation
por: Pilkington, Emily H., et al.
Publicado: (2017)

Evidence that the Human Innate Immune Peptide LL-37 may be a Binding Partner of Amyloid-β and Inhibitor of Fibril Assembly
por: De Lorenzi, Ersilia, et al.
Publicado: (2017)

Cathelicidin LL-37: An Antimicrobial Peptide with a Role in Inflammatory Skin Disease
por: Reinholz, Markus, et al.
Publicado: (2012)

Transformation of Human Cathelicidin LL-37 into Selective, Stable, and Potent Antimicrobial Compounds
por: Wang, Guangshun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qtt3enr00os5qj9i50jdkoqt3q