Cargando…

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N‐Acetyltransferase NAT2

N‐Acetyltransferases play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has been classified as an arylamine N‐acetyltransferase that mainly converts aromatic amines, hydroxylamines, and hydrazines. Herein, we demonstrate that the human arylamine N‐ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conway, Louis P., Rendo, Veronica, Correia, Mário S. P., Bergdahl, Ingvar A., Sjöblom, Tobias, Globisch, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497018/ https://www.ncbi.nlm.nih.gov/pubmed/32497306 http://dx.doi.org/10.1002/anie.202005915

Ejemplares similares

From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2
por: Laurieri, Nicola, et al.
Publicado: (2014)

Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status
por: Salazar-González, Raúl A., et al.
Publicado: (2022)

Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens
por: Duval, Romain, et al.
Publicado: (2016)

Arylamine N-Acetyltransferases in Mycobacteria
por: Sim, Edith, et al.
Publicado: (2008)

Arylamine N-Acetyltransferase 2 (NAT2) Genetic Diversity and Traditional Subsistence: A Worldwide Population Survey
por: Sabbagh, Audrey, et al.
Publicado: (2011)

Human Arylamine N-Acetyltransferase 1 (NAT1) Knockout in MDA-MB-231 Breast Cancer Cell Lines Leads to Transcription of NAT2
por: Carlisle, Samantha M., et al.
Publicado: (2022)

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system
por: Wakefield, Larissa, et al.
Publicado: (2008)

Folate-dependent hydrolysis of acetyl-coenzyme A by recombinant human and rodent arylamine N-acetyltransferases
por: Stepp, Marcus W., et al.
Publicado: (2015)

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
por: Doll, Mark A., et al.
Publicado: (2017)

Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer
por: Endo, Yumi, et al.
Publicado: (2014)

Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1: Functional effects and comparison with human
por: Boukouvala, Sotiria, et al.
Publicado: (2019)

Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis
por: Fayez, Diman, et al.
Publicado: (2018)

Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis
por: Barra, Fabio, et al.
Publicado: (2018)

Subcellular Protein Labeling by a Spatially Restricted Arylamine N-Acetyltransferase
por: Kleinpenning, Fleur, et al.
Publicado: (2018)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
por: Laurieri, Nicola, et al.
Publicado: (2014)

Correction to Subcellular Protein Labeling by a Spatially Restricted Arylamine N-Acetyltransferase
por: Kleinpenning, Fleur, et al.
Publicado: (2019)

Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa
por: Westwood, Isaac M, et al.
Publicado: (2007)

Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus
por: Liu, Xinning, et al.
Publicado: (2021)

Arylamine N-acetyl Transferase (NAT) in the blue secretion of Telescopium telescopium: xenobiotic metabolizing enzyme as a biomarker for detection of environmental pollution
por: Gorain, Bapi, et al.
Publicado: (2014)

Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine N-Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and in Vivo Studies
por: Ragunathan, Nilusha, et al.
Publicado: (2010)

Non-coding and intergenic genetic variants of human arylamine N-acetyltransferase 2 (NAT2) gene are associated with differential plasma lipid and cholesterol levels and cardiometabolic disorders
por: Hong, Kyung U., et al.
Publicado: (2023)

Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer
por: Rendo, Veronica, et al.
Publicado: (2020)

Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
por: Sim, E, et al.
Publicado: (2014)

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
por: Mahasneh, Amjad, et al.
Publicado: (2012)

Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens
por: Hein, David W., et al.
Publicado: (2022)

N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes.
por: Watanabe, M, et al.
Publicado: (1994)

Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes
por: Vangenot, Christelle, et al.
Publicado: (2019)

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
por: Kundu, Snehangshu, et al.
Publicado: (2021)

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice
por: Camporez, João Paulo, et al.
Publicado: (2017)

Characterization of Evolutionarily Conserved Trypanosoma cruzi NatC and NatA-N-Terminal Acetyltransferase Complexes
por: Ochaya, Stephen, et al.
Publicado: (2019)

Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant
por: Habil, Mariam R., et al.
Publicado: (2022)

Arylamines suppress their own activation and that of nitroarenes in V79 Chinese hamster cells by competing for acetyltransferases.
por: Kiefer, F, et al.
Publicado: (1994)

Polymorphisms in the Human Cytochrome P450 and Arylamine N-Acetyltransferase: Susceptibility to Head and Neck Cancers
por: Khlifi, Rim, et al.
Publicado: (2013)

Treatment of Rats with Apocynin Has Considerable Inhibitory Effects on Arylamine N-Acetyltransferase Activity in the Liver
por: Francis, Sheena, et al.
Publicado: (2016)

A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
por: Turiján-Espinoza, Eneida, et al.
Publicado: (2018)

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes
por: Salazar-González, Raúl A., et al.
Publicado: (2020)

N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease
por: Borlak, Juergen, et al.
Publicado: (2006)

NAT10, an RNA Cytidine Acetyltransferase, Regulates Ferroptosis in Cancer Cells
por: Dalhat, Mahmood Hassan, et al.
Publicado: (2023)

Determination of Arylamine N-Acetyltransferase 2 Acetylation Genotype by PCR and Phenotyping Using Dapsone Through High-Pressure Liquid Chromatography Assay: A Gender Wise Study
por: Akhter, Naheed, et al.
Publicado: (2019)

Effects of human arylamine N-acetyltransferase I knockdown in triple-negative breast cancer cell lines
por: Tiang, Jacky M, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_jnlpqraihq46sfe0i8ejk0fskf