Effects of gut microbiota on in vivo metabolism and tissue accumulation of cytochrome P450 3A metabolized drug: Midazolam

The link between drug‐metabolizing enzymes and gut microbiota is well established. In particular, hepatic cytochrome P450 (CYP) 3A activities are presumed to be affected by gut microbiota. However, there is no direct evidence that the gut microbiota affects CYP3A metabolism or the clearance of clini...

Descripción completa

Detalles Bibliográficos
Autores principales: Togao, Masao, Kawakami, Koji, Otsuka, Jun, Wagai, Gaku, Ohta‐Takada, Yuki, Kado, Shoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497050/
https://www.ncbi.nlm.nih.gov/pubmed/32562497
http://dx.doi.org/10.1002/bdd.2244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497050/
https://www.ncbi.nlm.nih.gov/pubmed/32562497
http://dx.doi.org/10.1002/bdd.2244

Ejemplares similares