Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons

Reduction in the expression or function of α5-subunit-containing GABA(A) receptors (α5GABA(A)Rs) leads to improvement in several hippocampus-dependent memory domains. However, studies thus far mostly lack anatomical specificity in terms of neuronal circuits and populations. We demonstrate that mice...

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Autores principales: Engin, Elif, Sigal, Maksim, Benke, Dietmar, Zeller, Anja, Rudolph, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497110/
https://www.ncbi.nlm.nih.gov/pubmed/32934095
http://dx.doi.org/10.1101/lm.052084.120
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author Engin, Elif
Sigal, Maksim
Benke, Dietmar
Zeller, Anja
Rudolph, Uwe
author_facet Engin, Elif
Sigal, Maksim
Benke, Dietmar
Zeller, Anja
Rudolph, Uwe
author_sort Engin, Elif
collection PubMed
description Reduction in the expression or function of α5-subunit-containing GABA(A) receptors (α5GABA(A)Rs) leads to improvement in several hippocampus-dependent memory domains. However, studies thus far mostly lack anatomical specificity in terms of neuronal circuits and populations. We demonstrate that mice with a selective knockdown of α5GABA(A)Rs in CA1 pyramidal neurons (α5CA1KO mice) show improved spatial and trace fear-conditioning memory. Unexpectedly, α5CA1KO mice were comparable to controls in contextual fear-conditioning but showed an impairment in context discrimination, suggesting fine-tuning of activity in CA1 pyramidal cell dendrites through α5-mediated inhibition might be necessary for distinguishing highly similar contexts.
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spelling pubmed-74971102021-10-01 Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons Engin, Elif Sigal, Maksim Benke, Dietmar Zeller, Anja Rudolph, Uwe Learn Mem Brief Communication Reduction in the expression or function of α5-subunit-containing GABA(A) receptors (α5GABA(A)Rs) leads to improvement in several hippocampus-dependent memory domains. However, studies thus far mostly lack anatomical specificity in terms of neuronal circuits and populations. We demonstrate that mice with a selective knockdown of α5GABA(A)Rs in CA1 pyramidal neurons (α5CA1KO mice) show improved spatial and trace fear-conditioning memory. Unexpectedly, α5CA1KO mice were comparable to controls in contextual fear-conditioning but showed an impairment in context discrimination, suggesting fine-tuning of activity in CA1 pyramidal cell dendrites through α5-mediated inhibition might be necessary for distinguishing highly similar contexts. Cold Spring Harbor Laboratory Press 2020-10 /pmc/articles/PMC7497110/ /pubmed/32934095 http://dx.doi.org/10.1101/lm.052084.120 Text en © 2020 Engin et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Engin, Elif
Sigal, Maksim
Benke, Dietmar
Zeller, Anja
Rudolph, Uwe
Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons
title Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons
title_full Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons
title_fullStr Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons
title_full_unstemmed Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons
title_short Bidirectional regulation of distinct memory domains by α5-subunit-containing GABA(A) receptors in CA1 pyramidal neurons
title_sort bidirectional regulation of distinct memory domains by α5-subunit-containing gaba(a) receptors in ca1 pyramidal neurons
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497110/
https://www.ncbi.nlm.nih.gov/pubmed/32934095
http://dx.doi.org/10.1101/lm.052084.120
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