Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

Monosaccharides are added to the hydrophilic face of a self‐assembled asymmetric Fe(II) metallohelix, using CuAAC chemistry. The sixteen resulting architectures are water‐stable and optically pure, and exhibit improved antiproliferative selectivity against colon cancer cells (HCT116 p53(+/+)) with r...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Hualong, Allison, Simon J., Brabec, Viktor, Bridgewater, Hannah E., Kasparkova, Jana, Kostrhunova, Hana, Novohradsky, Vojtech, Phillips, Roger M., Pracharova, Jitka, Rogers, Nicola J., Shepherd, Samantha L., Scott, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497174/
https://www.ncbi.nlm.nih.gov/pubmed/32489012
http://dx.doi.org/10.1002/anie.202006814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497174/
https://www.ncbi.nlm.nih.gov/pubmed/32489012
http://dx.doi.org/10.1002/anie.202006814

Ejemplares similares