Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with (18)F-Labeled Derivatives in Rats

[Image: see text] The 3,4-dichloro-N-(1-(dimethylamino)cyclohexyl)methyl benzamide scaffold was studied as a template for (18)F-positron emission tomography ((18)F-PET) radiotracer development emphasizing sensitivity to changes in opioid receptor (OR) occupancy over high affinity. Agonist potency, b...

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Detalles Bibliográficos
Autores principales: Ott, Julian, Spilhaug, Mona M., Maschauer, Simone, Rafique, Waqas, Jakobsson, Jimmy E., Hartvig, Karoline, Hübner, Harald, Gmeiner, Peter, Prante, Olaf, Riss, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497404/
https://www.ncbi.nlm.nih.gov/pubmed/32787100
http://dx.doi.org/10.1021/acs.jmedchem.0c00683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497404/
https://www.ncbi.nlm.nih.gov/pubmed/32787100
http://dx.doi.org/10.1021/acs.jmedchem.0c00683

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