A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes

A modified alcohol-enhanced (18)F-fluorodeboronation has been developed for the radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM. Unlike the [(18)F]KF/K(222) approach, this method tolerates the presence of sensitive heterocycles in Bpin precursors 4 and 8 allowing a one-step (18)F-fluorodeboron...

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Detalles Bibliográficos
Autores principales: Yuan, Gengyang, Shoup, Timothy M., Moon, Sung-Hyun, Brownell, Anna-Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497470/
https://www.ncbi.nlm.nih.gov/pubmed/33014351
http://dx.doi.org/10.1039/d0ra04943c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497470/
https://www.ncbi.nlm.nih.gov/pubmed/33014351
http://dx.doi.org/10.1039/d0ra04943c

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