A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes

A modified alcohol-enhanced (18)F-fluorodeboronation has been developed for the radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM. Unlike the [(18)F]KF/K(222) approach, this method tolerates the presence of sensitive heterocycles in Bpin precursors 4 and 8 allowing a one-step (18)F-fluorodeboron...

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Autores principales: Yuan, Gengyang, Shoup, Timothy M., Moon, Sung-Hyun, Brownell, Anna-Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497470/
https://www.ncbi.nlm.nih.gov/pubmed/33014351
http://dx.doi.org/10.1039/d0ra04943c
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author Yuan, Gengyang
Shoup, Timothy M.
Moon, Sung-Hyun
Brownell, Anna-Liisa
author_facet Yuan, Gengyang
Shoup, Timothy M.
Moon, Sung-Hyun
Brownell, Anna-Liisa
author_sort Yuan, Gengyang
collection PubMed
description A modified alcohol-enhanced (18)F-fluorodeboronation has been developed for the radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM. Unlike the [(18)F]KF/K(222) approach, this method tolerates the presence of sensitive heterocycles in Bpin precursors 4 and 8 allowing a one-step (18)F-fluorodeboronation on the fully automated TRACERlab™ FX(FN) platform.
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spelling pubmed-74974702020-10-02 A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes Yuan, Gengyang Shoup, Timothy M. Moon, Sung-Hyun Brownell, Anna-Liisa RSC Adv Chemistry A modified alcohol-enhanced (18)F-fluorodeboronation has been developed for the radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM. Unlike the [(18)F]KF/K(222) approach, this method tolerates the presence of sensitive heterocycles in Bpin precursors 4 and 8 allowing a one-step (18)F-fluorodeboronation on the fully automated TRACERlab™ FX(FN) platform. The Royal Society of Chemistry 2020-07-02 /pmc/articles/PMC7497470/ /pubmed/33014351 http://dx.doi.org/10.1039/d0ra04943c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Yuan, Gengyang
Shoup, Timothy M.
Moon, Sung-Hyun
Brownell, Anna-Liisa
A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes
title A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes
title_full A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes
title_fullStr A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes
title_full_unstemmed A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes
title_short A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes
title_sort concise method for fully automated radiosyntheses of [(18)f]jnj-46356479 and [(18)f]fitm via cu-mediated (18)f-fluorination of organoboranes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497470/
https://www.ncbi.nlm.nih.gov/pubmed/33014351
http://dx.doi.org/10.1039/d0ra04943c
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