Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

[Image: see text] Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target of CbA remain unknown. Here, we develop...

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Detalles Bibliográficos
Autores principales: Tranter, Dale, Paatero, Anja O., Kawaguchi, Shinsaku, Kazemi, Soheila, Serrill, Jeffrey D., Kellosalo, Juho, Vogel, Walter K., Richter, Uwe, Mattos, Daphne R., Wan, Xuemei, Thornburg, Christopher C., Oishi, Shinya, McPhail, Kerry L., Ishmael, Jane E., Paavilainen, Ville O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497630/
https://www.ncbi.nlm.nih.gov/pubmed/32608972
http://dx.doi.org/10.1021/acschembio.0c00325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497630/
https://www.ncbi.nlm.nih.gov/pubmed/32608972
http://dx.doi.org/10.1021/acschembio.0c00325

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