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Role of Membrane Tension Sensitive Endocytosis and Rho GTPases in the Uptake of the Alzheimer’s Disease Peptide Aβ(1-42)

[Image: see text] Intraneuronal accumulation of amyloid-β (Aβ) is an early pathological signum of Alzheimer’s disease, and compartments of the endolysosomal system have been implicated in both seeding and cell–cell propagation of Aβ aggregation. We have studied how clathrin-independent mechanisms co...

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Detalles Bibliográficos
Autores principales: Wesén, Emelie, Lundmark, Richard, Esbjörner, Elin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497631/
https://www.ncbi.nlm.nih.gov/pubmed/32497421
http://dx.doi.org/10.1021/acschemneuro.0c00053