Cargando…

Binding Site Interactions of Modulators of Breast Cancer Resistance Protein, Multidrug Resistance-Associated Protein 2, and P-Glycoprotein Activity

[Image: see text] ATP-binding cassette (ABC)-transporters protect tissues by pumping their substrates out of the cells in many physiological barriers, such as the blood–brain barrier, intestine, liver, and kidney. These substrates include various endogenous metabolites, but, in addition, ABC transpo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Feng, Ghemtio, Leo, Grazhdankin, Evgeni, Wipf, Peter, Xhaard, Henri, Kidron, Heidi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497665/ https://www.ncbi.nlm.nih.gov/pubmed/32496785 http://dx.doi.org/10.1021/acs.molpharmaceut.0c00155

Ejemplares similares

Applying Linear and Non-Linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug
por: del Amo, Eva M., et al.
Publicado: (2013)

Correction: Applying Linear and Non-Linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug
por: del Amo, Eva M., et al.
Publicado: (2015)

Predictive classification models and targets identification for betulin derivatives as Leishmania donovani inhibitors
por: Zhang, Yuezhou, et al.
Publicado: (2018)

IDAAPM: integrated database of ADMET and adverse effects of predictive modeling based on FDA approved drug data
por: Legehar, Ashenafi, et al.
Publicado: (2016)

Analysis of Biologics Molecular Descriptors towards Predictive Modelling for Protein Drug Development Using Time-Gated Raman Spectroscopy
por: Itkonen, Jaakko, et al.
Publicado: (2022)

The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer
por: Hu, Wen-Qing, et al.
Publicado: (2009)

Interaction of tamoxifen with the multidrug resistance P-glycoprotein.
por: Callaghan, R., et al.
Publicado: (1995)

Proteins regulating the intercellular transfer and function of P-glycoprotein in multidrug-resistant cancer
por: Pokharel, Deep, et al.
Publicado: (2017)

Multidrug resistance associated proteins in multidrug resistance
por: Sodani, Kamlesh, et al.
Publicado: (2012)

The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of Nanosystems on Multidrug Resistance Protein-1 and P-glycoprotein
por: Mello, Francisco V.C., et al.
Publicado: (2020)

Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance
por: Swartz, Douglas J., et al.
Publicado: (2014)

Modulation of multidrug resistance proteins by statins in human neuroblastoma
por: Sieczkowski, Evelyn, et al.
Publicado: (2008)

Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance–Associated Protein 2 at the Blood–Brain Barrier
por: Cannon, Ronald E., et al.
Publicado: (2020)

Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists
por: Lautala, Saara, et al.
Publicado: (2023)

CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated protein.
por: Jansen, W. J., et al.
Publicado: (1998)

99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein.
por: Hendrikse, N. H., et al.
Publicado: (1998)

The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducers
por: Frye, William J. E., et al.
Publicado: (2023)

B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1
por: Zhou, H, et al.
Publicado: (2013)

In vivo efficacy of XR9051, a potent modulator of P-glycoprotein mediated multidrug resistance
por: Mistry, P, et al.
Publicado: (1999)

Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines
por: Mohana, S., et al.
Publicado: (2018)

Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
por: van Kalken, C. K., et al.
Publicado: (1993)

Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein
por: Karthika, Chenmala, et al.
Publicado: (2022)

Mechanism of multidrug resistance to chemotherapy mediated by P-glycoprotein (Review)
por: Tian, Yichen, et al.
Publicado: (2023)

Human La Protein: An RNA-Binding Protein Involved in Ovarian Cancer Development and Multidrug Resistance
por: Huang, Xuan, et al.
Publicado: (2020)

Multidrug Resistance‐associated Protein‐mediated Multidrug Resistance Modulated by Cyclosporin A in a Human Bladder Cancer Cell Line
por: Kim, Wun‐Jae, et al.
Publicado: (1995)

Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines
por: Bergman, A M, et al.
Publicado: (2003)

Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile
por: Dingle, Kate E., et al.
Publicado: (2023)

Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
por: Versantvoort, C. H., et al.
Publicado: (1993)

The Syk inhibitor R406 is a modulator of P-glycoprotein (ABCB1)-mediated multidrug resistance
por: Duran, George E., et al.
Publicado: (2019)

Drug Resistance in Cortical and Hippocampal Slices from Resected Tissue of Epilepsy Patients: No Significant Impact of P-Glycoprotein and Multidrug Resistance-Associated Proteins
por: Sandow, Nora, et al.
Publicado: (2015)

A critical review on modulators of Multidrug Resistance Protein 1 in cancer cells
por: Poku, Vivian Osei, et al.
Publicado: (2022)

Bromocriptine Reverses P‐Glycoprotein‐mediated Multidrug Resistance in Tumor Cells
por: Shiraki, Nobuaki, et al.
Publicado: (2002)

Screening of Natural Compounds as P-Glycoprotein Inhibitors against Multidrug Resistance
por: Marques, Sérgio M., et al.
Publicado: (2021)

Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance.
por: Gekeler, V., et al.
Publicado: (1996)

Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)
por: Lalloo, Anita K, et al.
Publicado: (2004)

Novel Heat Shock Protein 90 Inhibitors Suppress P-Glycoprotein Activity and Overcome Multidrug Resistance in Cancer Cells
por: Dinić, Jelena, et al.
Publicado: (2019)

Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells
por: Colotti, Gianni, et al.
Publicado: (2014)

Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)
por: DENG, WEN, et al.
Publicado: (2013)

Yeast ABC proteins involved in multidrug resistance
por: Piecuch, Agata, et al.
Publicado: (2013)

Characterization of Ionizable Groups’ Environments in Proteins and Protein–Ligand Complexes through a Statistical Analysis of the Protein Data Bank
por: Borrel, Alexandre, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3qc5i3qr87pj0095aot8hlp1k6