Coverage-dependent bias creates the appearance of binary splicing in single cells

Single-cell RNA sequencing provides powerful insight into the factors that determine each cell’s unique identity. Previous studies led to the surprising observation that alternative splicing among single cells is highly variable and follows a bimodal pattern: a given cell consistently produces eithe...

Descripción completa

Detalles Bibliográficos
Autores principales: Buen Abad Najar, Carlos F, Yosef, Nir, Lareau, Liana F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498265/
https://www.ncbi.nlm.nih.gov/pubmed/32597758
http://dx.doi.org/10.7554/eLife.54603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498265/
https://www.ncbi.nlm.nih.gov/pubmed/32597758
http://dx.doi.org/10.7554/eLife.54603

Ejemplares similares