Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy

Extracellular vesicles (EVs) hold great promise for transporting CRISPR–Cas9 RNA-guided endonucleases (RNP) throughout the body. However, the cell-selective delivery of EVs is still a challenge. Here, we designed valency-controlled tetrahedral DNA nanostructures (TDNs) conjugated with DNA aptamer, a...

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Detalles Bibliográficos
Autores principales: Zhuang, Jialang, Tan, Jizhou, Wu, Chenglin, Zhang, Jie, Liu, Ting, Fan, Chunhai, Li, Jiaping, Zhang, Yuanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498310/
https://www.ncbi.nlm.nih.gov/pubmed/32810272
http://dx.doi.org/10.1093/nar/gkaa683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498310/
https://www.ncbi.nlm.nih.gov/pubmed/32810272
http://dx.doi.org/10.1093/nar/gkaa683

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